Analisis In-Silico Potensi Senyawa Antioksidan Batang Spatholobus littoralis (Bajakah)
DOI:
https://doi.org/10.29407/4dwtnm59Keywords:
Bajakah, Spatholobus littoralis, antioksidan, in silico, ADMET, Lipinski, toksisitasAbstract
Bajakah is a traditional medicinal plant native to the forests of Kalimantan and is known to contain various active compounds such as flavonoids, hydroquinone, alkaloids, phenols, and terpenoids. This study aims to analyze the antioxidant potential of compounds found in the stem of Spatholobus littoralis through in silico methods, including drug-likeness evaluation based on Lipinski’s Rule, ADMET prediction (absorption, distribution, metabolism, excretion, and toxicity), and toxicity assessment using ProTox-3.0.
The results showed that all five compounds complied with Lipinski’s Rule and exhibited high gastrointestinal absorption and reasonably good bioavailability. These compounds also demonstrated diverse antioxidant activities, such as free radical scavenging and inhibition of oxidative enzymes. Based on toxicity predictions, flavonoids and terpenoids were classified as Class V (non-toxic), alkaloids as Class IV (slightly toxic), and hydroquinone and phenols as Class III (moderately toxic), with hydroquinone showing the highest toxicity indicated by an LD₅₀ value of 225 mg/kg. These findings support the potential of bajakah stem as a promising source of natural antioxidant compounds for further development.
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