Mengungkap Potensi Senyawa Bioaktif Air Kelapa (Cocos Nucifera) Sebagai Obat Detoksifikasi Racun Merkuri
DOI:
https://doi.org/10.29407/qxr3b244Keywords:
bioactive, Cocos nucifera, mercuryAbstract
This study aims to reveal the potential of compounds found in coconut water (Cocos nucifera) as detoxifying agents against mercury toxicity. The method used was a descriptive–explorative study with the collection and identification of chemical compound data from the literature. The types of active compounds present in Cocos nucifera were compiled through literature review. Compound IDs, canonical SMILES, biological activities, and Pa values were analyzed in silico using web servers (PubChem and Way2Drug) with a Pa threshold of > 0.7 to predict potential biological activities.
Based on the literature search, three active chemical compounds were identified in Cocos nucifera: valine, tyrosine, and methionine. Valine showed activity as a superoxide dismutase inhibitor (inhibiting oxidative damage) (0.893), a glutamate uptake inhibitor (inhibiting glutamate absorption) (0.854), and a serine–pyruvate transaminase inhibitor (preventing liver damage caused by mercury exposure) (0.833). Tyrosine exhibited activity as a diiodophenylpyruvate reductase inhibitor (preventing the conversion of mercury into toxic forms) (0.928), an FMO3 substrate (producing antioxidants) (0.824), and a muramoyltetrapeptide carboxypeptidase inhibitor (inhibiting mercury entry into cells) (0.799). Finally, methionine showed activity as a pro-opiomelanocortin converting enzyme inhibitor (preventing nerve damage) (0.738), a CYP2H substrate (regulating xenobiotic substrates) (0.717), and a flavin-containing monooxygenase substrate (involved in xenobiotic metabolism) (0.787).
These three compounds have diverse targets in the human body. The results indicate that all three compounds have high Pa scores and various potential activities, particularly in inhibiting enzymes associated with mercury poisoning. This study is expected to contribute to scientific knowledge and serve as a foundation for further research on the development of local plant-based treatments for mercury detoxification.
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