Analisis In Silico Senyawa Kimia pada Daun Anredera cordifolia (Binahong) sebagai Antidiabetes
DOI:
https://doi.org/10.29407/1mw3sw32Keywords:
Anredera cordifolia, Antidiabetic compounds, In silico analysis, Toxicity predictionAbstract
The objective of this study was to identify chemical compounds in Anredera cordifolia leaves with antidiabetic potential using an in silico approach. Four compounds were analyzed, namely morin, myricetin, vitexin, and isovitexin. The study employed in silico analysis using several bioinformatics platforms, including SwissADME, Way2Drug, and ProTox-3.0. The results indicated that morin was the most promising candidate, as it fulfilled all Lipinski’s Rule of Five criteria, exhibited high gastrointestinal absorption, and belonged to a low toxicity class with an LD₅₀ value of 3919 mg/kg. In contrast, the other compounds demonstrated limitations in pharmacological feasibility and toxicity profiles. This study supports the potential utilization of Anredera cordifolia leaves as a natural source of antidiabetic compounds for the development of alternative therapeutic agents
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